Article
Understand the disease
prevent disease
Treatment programs
Postoperative recovery
    
How to choose adjuvant chemotherapy regimen for colon cancer?
2023/11/26

ADVERTISEMENT

Most colon cancers originate from precancerous lesions that can be detected and removed by colonoscopy, but cancers after colonoscopy (interval cancers) still account for 9% of all colon cancers. Incomplete colonoscopies, missed diagnoses, rapid Progressive lesions, iatrogenic tumor dissemination, and incomplete resection of lesions may be causes of interval colon cancer, emphasizing the importance of accurate detection and complete resection of all polyps.

Content points:

1. Adjuvant chemotherapy after colon cancer surgery 2. When does colon cancer require targeted therapy?

ADVERTISEMENT

At present, the preferred method for the treatment of colon cancer is radical surgery, followed by radiotherapy and chemotherapy. The new view is that if the metastatic lesions can be resected at the same time, they should be resected together with the colon cancer lesions.

If the metastases cannot be resected, then Adjuvant chemotherapy is performed first, and then resection is performed after stabilization. For unresectable tumors or those with distant metastases, local radiotherapy is also one of the commonly used methods in the treatment of advanced colon cancer. It can shrink the tumor and improve the patient's symptoms. It is often combined with other Combined application of treatment options.

ADVERTISEMENT

NO.1 Adjuvant chemotherapy after colon cancer surgery Clinical research on adjuvant chemotherapy after colon cancer surgery began in the 1960s. Research results show that adjuvant chemotherapy with fluorouracil and leucovorin can bring survival benefits to patients. Follow-up studies have shown Capecitabine has shown greater efficacy in adjuvant chemotherapy for stage III colon cancer, and oxaliplatin and irinotecan have significant efficacy in advanced colon cancer. Some patients can also use a simple fluorouracil-based chemotherapy regimen. At the same time, comprehensive factors such as the patient's disease stage, physical condition, age, etc. must also be taken into consideration.

ADVERTISEMENT

The chemotherapy regimen for advanced colorectal cancer can be a comprehensive treatment regimen of fluorouracil combined with platinum-based drugs combined with irinotecan drugs and combined with two targeted drugs so that patients can achieve longer survival. Time. Nowadays, treatment options such as immunotherapy can be applied to some special types of colorectal cancer, which can also lead to longer survival times.

NO.2 When does colon cancer require targeted therapy?

With the continuous advancement of medical technology and the deepening of research on tumor molecular targeting, the therapeutic effect of targeted drugs for colon cancer is getting better and better, and the incidence of adverse reactions is getting lower and lower. However, not all patients with colon cancer are suitable for targeted drugs. treatment.

ADVERTISEMENT

The effective rate of chemotherapy is 40%-50%. After combined with targeted therapy, the effective rate is increased to 70%. Current clinical studies have found that the combination of three drugs with targeted therapy, such as FOLFOXIRI combined with bevacizumab, can reduce the risk of late-stage disease after treatment. The survival rate of bowel cancer patients is >40 months, and there are even reports that some patients can survive for 5 years.

The selection of targeted drugs should be based on the patient's status, including genetic status. For example, bevacizumab should be selected for K-ras mutation, cetuximab should be selected for patients with full ras wild-type, and immunotherapy should be selected for patients with MSI-H type. Therefore, genetic Testing is very important for treatment selection.

ADVERTISEMENT

The principles for selecting targeted drugs for colon cancer in different parts of the body are different. For patients with wild-type left colon cancer, cetuximab is preferred, while for patients with right colon cancer, bevacizumab is selected. At this time, it is necessary to follow Doctors to discuss targeted drug treatment options.

Restoring intestinal health is an important theme pursued by modern medical health. Especially for people who are already troubled by diseases. By colonizing the intestines with beneficial bacteria, the intestinal microecological balance is adjusted. It helps to alleviate the toxic side effects of radiotherapy and chemotherapy. Inhibits the growth of tumor cells.

The acid produced by the metabolism of Bacteroides fragilis BF839 can regulate and promote intestinal peristalsis, prevent the colonization of pathogenic bacteria, prevent the adhesion and invasion of potential pathogenic bacteria and their toxins in intestinal mucosal epithelial cells, and is beneficial to recovery. Colon health plays an important role.

ADVERTISEMENT

ADVERTISEMENT

10 Surprising Foods Colon Cancer Patients Should Avoid Unnoticed Everyday Risks
2023/11/29
Every Stage Counts: Unveiling the Cost Curve of Colon Cancer Surgery
2023/11/29

ADVERTISEMENT

5 Must-Know Tips on Post-Colorectal Cancer Surgery
2023/11/28
10 Everyday Habits You Didn't Know Could Lead to Colon Cancer: A Preventive Tale
2023/11/28
Colon Cancer or Just Indigestion? 5 Warning Signs You're Likely Ignoring
2023/11/27
Men vs Women: The Surprising Gender Gap in Colon Cancer Risk
2023/11/27
Is adjuvant chemotherapy a must for colon cancer? How to choose?
2023/11/26
How to choose adjuvant chemotherapy regimen for colon cancer?
2023/11/26
There are 4 symptoms, most of which are early stage of colon cancer!
2023/11/25
In the early stages of colon cancer, the body will have 4 "differences"
2023/11/25